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Laboratory Introduction

The Southwest Medical University Radiology and Diabetes Research Laboratory is dedicated to cutting-edge research in the fields of radiology and diabetes. Equipped with state-of-the-art imaging technology and precision molecular biology platforms, our lab is capable of conducting research that spans from basic science to clinical applications. In radiology, we focus on advanced imaging diagnostics, radiation therapy, and the development of radiopharmaceuticals. Our work aims to enhance the accuracy of disease diagnosis and improve patient outcomes through innovative approaches.

Foundations

Supported by the National Nature Scientific Foundation of China, the Sichuan Provincial Science Fund for Distinguished Young Scholars, the Applied Basic Research Program of Sichuan Province and the Fundamental Research Funds for the Central Universities.

Key Research Achievements and Publications

Advances and prospects in metabolic engineering of Zymomonas mobilis

Biorefinery of biomass-based biofuels and biochemicals by microorganisms is a competitive alternative of traditional petroleum refineries. Zymomonas mobilis is a natural ethanologen with many desirable characteristics, which makes it an ideal industrial microbial biocatalyst for commercial production of desirable bioproducts through metabolic engineering.

Complete genome sequence and the expression pattern of plasmids of the model ethanologen...

In this study, we determined the complete chromosome and plasmid sequences of ZM4 and its engineered xylose-utilizing derivatives 2032 and 8b. Compared to previously published and revised ZM4 chromosome sequences, the ZM4 chromosome sequence reported here contains 65 nucleotide sequence variations as well as a 2400-bp insertion.

Progress and perspective on lignocellulosic hydrolysate inhibitor tolerance improvement in Zymomonas mobilis

Pretreatment is the key step to overcome the recalcitrance of lignocellulosic biomass making sugars available for subsequent enzymatic hydrolysis and microbial fermentation. During the process of pretreatment and enzymatic hydrolysis as well as fermentation, various toxic compounds may be generated with strong inhibition on cell growth and the metabolic capacity of fermenting strains.

Identification of inhibitors in lignocellulosic slurries and determination of their effect on hydrocarbon-producing microorganisms

The aim of this work was to identify inhibitors in pretreated lignocellulosic slurries, evaluate high-throughput screening strategies, and investigate the impact of inhibitors on potential hydrocarbon-producing microorganisms. Compounds present in slurries that could inhibit microbial growth were identified through a detailed analysis of saccharified slurries by applying a combination of approaches of high-performance liquid chromatography, GC-MS, LC-DAD-MS, and ICP-MS.